Size：100 μg
Price：$ 1600
Brand：NewEast 
Place of Origin：USA
Immunogen：
| Cat.#: 12230 | ||
| Product Name: Human ADORA2A Full Length Protein | ||
| Size : 10 µg, 50 µg and 100 µg | ||
| Synonyms: A2aR; ADORA2; RDC8 | ||
| Target: ADORA2A | ||
| UNIPROT ID: P29274 | ||
| Description: Human ADORA2A full length protein membrane nanoparticles (MNPs) | ||
| Background: A member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. | ||
| Species/Host: HEK293 | ||
| Molecular Weight: The human full length ADORA2A protein has a MW of 44.7 kDa | ||
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. | ||
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. | ||
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