Size：100 μg
Price：$ 389
Brand：NewEast 
Place of Origin：USA
Immunogen：
| Cat.#: 12274 |
| Product Name: Human CFH Protein |
| Size : 10 µg, 50 µg and 100 µg |
| Synonyms: FH;HF;HF1;HF2;HUS;FHL1;AHUS1;AMBP1;ARMD4;ARMS1;CFHL3 |
| Target: CFH |
| UNIPROT ID: P08603 |
| Description: Recombinant human CFH Protein with C-terminal 10xHis tag |
| Background: This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011] |
| Species/Host: HEK293 |
| Molecular Weight: The protein has a predicted molecular mass of 138.4 kDa after removal of the signal peptide. The apparent molecular mass of CFH-His is approximately 130-250 kDa due to glycosylation. |
| Molecular Characterization: CFH(Glu19-Arg1231) 10×His tag |
| Purity: The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Figure 1. Human CFH Protein, His Tag on SDS-PAGE under reducing condition. |
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