Size：100 μg
Price：$ 479
Brand：NewEast 
Place of Origin：USA
Immunogen：
| Cat.#: 12287 |
| Product Name: Human SCUBE2(441-659) Protein |
| Size : 10 µg, 50 µg and 100 µg |
| Synonyms: CEGP1;Scube/You |
| Target: SCUBE2 |
| UNIPROT ID: Q9NQ36 |
| Description: Recombinant human SCUBE2(441-659) protein with C-terminal human Fc tag |
| Background: Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).[UniProtKB/Swiss-Prot Function] |
| Species/Host: HEK293 |
| Molecular Weight: The protein has a predicted molecular mass of 50.2 kDa after removal of the signal peptide. The apparent molecular mass of SCUBE2(441-659)-hFc is approximately 35-55 kDa due to glycosylation. |
| Molecular Characterization: SCUBE2(Asp441-Asn659 ) hFc(Glu99-Ala330) |
| Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Figure 1. Human SCUBE2 (441-659) Protein, hFc Tag on SDS-PAGE under reducing condition. |
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