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TIGIT (DM178) Rabbit mAb

28521

Size:100 μg Price:$ 445 Brand:NewEast Place of Origin:USA Immunogen:

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Cat.#:   28521
Product Name:   Anti-TIGIT(DM178) Rabbit Monoclonal Antibody
Synonyms:   TIGIT;VSIG9;VSTM3
Description:    Anti-TIGIT antibody(DM178) Rabbit Monoclonal Antibody
Background:    This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.
Applications:    ELISA; Flow Cyt
Recommended Dilutions:    ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit IgG
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human TIGIT
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-TIGIT (DM178) on Expi293 cells transfected with human TIGIT (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).

Figure 2. Competition assay demonstrating DM178 blockade of CD155 binding to Jurkat cell line transfected with human TIGIT,and competitive activity is better than etigilimab biosimilar.
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