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IL17RA (DM126) Rabbit mAb

28471

Size:100 μg Price:$ 445 Brand:NewEast Place of Origin:USA Immunogen:

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Cat.#:   28471
Product Name:   Anti-IL17RA(DM126) Rabbit Monoclonal Antibody
Synonyms:   CD217;CDw217;IL-17RA;IL17R;CANDF5;hIL-17R
Description:    Anti-IL17RA antibody(DM126) Rabbit Monoclonal Antibody
Background:    Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors; this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications:    ELISA; Flow Cyt
Recommended Dilutions:    ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:    Rabbit
Isotype:    Rabbit IgG
Purification:    Purified from cell culture supernatant by affinity chromatography
Species Reactivity:    Human IL17RA
Constituents:    Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.
Storage & Shipping:    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. ELISA plate pre-coated by 1 µg/ml (100 µl/well) Human IL-17RA protein, His tagged protein 11279 can bind Rabbit anti-IL-17RA monoclonal antibody  (clone: DM126) in a linear range of 0. 3-15 ng/ml.

Figure 2. Flow cytometry analysis with Anti-IL-17RA  (DM126) on Expi293 cells transfected with human IL17RA(Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
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