SOCS1 Rabbit pAb

219997

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S219997

Product Name: Anti-SOCS1 Rabbit Polyclonal Antibody

Synonyms: JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; TIP-3; AISIMD; SOCS-1

UNIPROT ID: O15524 (Gene Accession - NP_003736 )

Background: This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

Immunogen: Synthetic peptide of human SOCS1

Applications: ELISA, WB, IHC

Recommended Dilutions: IHC: 100-300;WB: 1000-5000;ELISA: 2000-10000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse, Rat

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Signal Transduction, Epigenetics and Nuclear Signaling, Immunology

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 219997(SOCS1 Antibody) at a dilution of 1/90(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 219997(Anti-SOCS1 Antibody) at dilution 1/90.
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using 219997(Anti-SOCS1 Antibody) at a dilution of 1/90.	In comparision with the IHC on the left, the same paraffin-embedded Human ovarian cancer tissue is first treated with synthetic peptide and then with D260748(Anti-SOCS1 Antibody) at dilution 1/90.
Gel: 12%SDS-PAGE, Lysate: 40 μg; Lane: 231 cell lysate; Primary antibody: 219997(SOCS1 Antibody) at dilution 1/1700; Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/5000 dilution; Exposure time: 5 minutes

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SOCS1 Rabbit pAb

TUBB3 Rabbit pAb

GAPDH Rabbit pAb

TUBA4A Rabbit pAb

ALB Rabbit pAb

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