CD40 Rabbit pAb

220440

Size：100 μl Price：$ 349 Brand：NewEast Place of Origin：USA Immunogen：

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Cat.#: S220440

Product Name: Anti-CD40 Rabbit Polyclonal Antibody

Synonyms: p50; Bp50; CDW40; TNFRSF5

UNIPROT ID: P25942 (Gene Accession - NP_001241 )

Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

Immunogen: Synthetic peptide of human CD40

Applications: ELISA, IHC

Recommended Dilutions: IHC: 100-300; ELISA: 2000-10000

Host Species: Rabbit

Clonality: Rabbit Polyclonal

Isotype: Immunogen-specific rabbit IgG

Purification: Antigen affinity purification

Species Reactivity: Human, Mouse

Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.05% Sodium Azide and 40% glycerol

Research Areas: Cardiovascular, Immunology, Stem Cells

Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing

Immunohistochemistry analysis of paraffin embedded Human liver cancer tissue using 220440(CD40 Antibody) at a dilution of 1/70(Cytoplasm).	In comparision with the IHC on the left, the same paraffin-embedded Human liver cancer tissue is first treated with the synthetic peptide and then with 220440(Anti-CD40 Antibody) at dilution 1/70.
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using 220440(Anti-CD40 Antibody) at a dilution of 1/70.	In comparision with the IHC on the left, the same paraffin-embedded Human gastric cancer tissue is first treated with synthetic peptide and then with D261532(Anti-CD40 Antibody) at dilution 1/70.

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