Size：100 μl
Price：$ 349
Brand：NewEast 
Place of Origin：USA
Immunogen：
| Cat.#: N261203 | ||||
| Product Name: Anti-CD45 Mouse Monoclonal Antibody | ||||
| Synonyms: PTPRC; CD45; Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; L-CA; T200; CD antigen CD45 | ||||
| UNIPROT ID: P08575 | ||||
| Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. | ||||
| Immunogen: Purified recombinant fragment of human PTPRC (AA: 928-989) expressed in E. Coli. | ||||
| Applications: WB,IHC-P | ||||
| Recommended Dilutions: WB: 1/500-1/1000 IHC: 1/50-1/100 | ||||
| Host Species: Mouse | ||||
| Clonality: Mouse Monoclonal | ||||
| Clone ID: 5D3A3 | ||||
| MW: Calculated MW: 147 kDa; Observed MW: 180-240kDa | ||||
| Isotype: IgG1 | ||||
| Purification: Affinity Purified | ||||
| Species Reactivity: Human,Mouse | ||||
| Conjugation: Unconjugated | ||||
| Modification: Unmodified | ||||
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.3 containing 50% glycerol, 0.5% BSA and 0.02% sodium azide | ||||
| Research Areas: Immunology | ||||
| Storage & Shipping: Store at -20°C. Avoid repeated freezing and thawing | ||||
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Bioactive Transmembrane Proteins Antibodies for Transmembrane Proteins G Protein | GTPase
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